Formulation and evaluation of mucoadhesive glipizide microspheres
نویسندگان
چکیده
منابع مشابه
Formulation and evaluation of mucoadhesive glipizide films.
Glipizide is mainly absorbed in the proximal areas of the gastrointestinal tract. The purpose of this study was formulation and evaluation of mucoadhesive films to prolong the stay of drug in its absorption area. Glipizide was formulated in a mucoadhesive film that could be retained in the stomach for prolonged intervals. Polymeric films were designed with various compositions of hydroxypropyl ...
متن کاملFormulation and Evaluation of Mucoadhesive Microspheres for Intra -nasal Delivery
Intranasal administration is an ideal alternative to the parenteral route for systemic drug delivery. Various conventional dosage forms have been employed for this purpose but they lack to provide the desired bioavailability of the drug due to poor residence time and faster clearance in the nasal cavity. Formulating multiparticulate system with mucoadhesive polymers may provide a significant in...
متن کاملFormulation and evaluation of Bacillus coagulans-loaded hypromellose mucoadhesive microspheres
Development of a novel delivery system has been attempted to deliver viable probiotic cells into the gut for a prolonged period of time while maintaining high numbers of viable cells within the formulation throughout the shelf-life of the product and during the gastrointestinal transit. Core mucoadhesive microspheres of Bacillus coagulans were developed employing several grades of hypromellose,...
متن کاملFormulation and in Vitroevaluation of Glipizide Mucoadhesive Buccal Tablets
The aim of study was to prepare and characterize mucoadhesive buccal tablets of glipizide using different Mucoadhesive polymers such as Carbopol 940, Sodium alginate and HPMC K15M in combination. Twenty one formulation were developed with different concentration of mucoadhesive polymers in each formulation.The formulated buccal tablets were tested for surface pH,in vitro drug release and moistu...
متن کاملFormulation and Evaluation of Propranolol Hydrochloride-Loaded Carbopol-934P/Ethyl Cellulose Mucoadhesive Microspheres
The purpose of this research was to formulate and systemically evaluate in-vitro and in-vivo performances of mucoadhesive propranolol hydrochloride microspheres for its potential use in the treatment of hypertension, myocardial infraction and cardiac arrhythmias. Propranolol hydrochloride mucoadhesive microspheres, containing carbopol-934P as mucoadhesive polymer and ethyl cellulose as carrier ...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2005
ISSN: 1530-9932
DOI: 10.1208/pt060110